Job Description

The Vertex Internship Program offers students the opportunity to learn about the pharmaceutical industry from a hands-on perspective. You will be working closely with and learning from some of the brightest people in the industry. When you join our internship program you should not be surprised to see that our environment is one that is innovative and team oriented, where collaboration is not just a word, and "we are relentless" is in everything we do. Students can expect to be challenged by their project plan, connect with other interns,and feel valued by the Vertex community. Not only will interns learn about their day-to-day tasks through their specific work assignments, but they will interact and have exposure to our organizational leaders and their teams.

Job Summary:

Vertex Pharmaceuticals is seeking a highly motivated intern PhD student to join our Drug Metabolism and Pharmacokinetics (DMPK) group in San Diego, CA. The successful candidate will use LCMS Methods for selectivity analysis on protein targets. Specific goals for this position include the identification of signature peptides of protein of interest, optimization of proteolytic digestion conditions and sample preparation conditions to yield maximum desired peptides, and optimization of the LC-MS/MS conditions necessary to develop, produce a robust and reproducible bioanalytical method in disease-relevant cells or preclinical species and perform bioinformatics analysis of the results. They will be fully immersed in the day-to-day operations of a drug discovery group. An ideal candidate is curious, self-motivated, has a strong drive to learn new things and thrives in both independent and team roles.

Key Responsibilities:

• Perform compound treatment in cells and cell harvesting
• Perform proteomics sample preparation
• Use LC-MS to analyze samples
• Analyze LC-MS raw data using proteomics software
• Perform bioinformatics analysis for the results
• Interpret and present the results

Qualifications:

• Ph.D. student in Biological or Chemical Sciences plus minimum of 3 years experience in proteomics field.
• Experience in mass spectrometry-based quantitative proteomics (TMT, SILAC, PRM or LFQ)
• Experience analyzing and interpreting LC-MS data using custom, public, and commercially available software suites, like Proteome Discoverer, MaxQuant, DIA-NN
• Must be proficient with software such as Microsoft Word, Excel, PowerPoint, Graph Pad Prism, and other scientific software, R or Phython
• Attention to detail in documenting, executing and analyzing experiment
• Legally authorized to work in the United States
• Permanent legal authorization to work in the United States
• Candidate must be enrolled in an advanced degree program if graduating before June 2025
• Candidate must be available to work full-time, 40 hours per week from June - September 2025

Program Dates: June - September 2025, Full Time

Pay Range $33.00 - $50.00 USD/hour

This job posting is for a temporary role with a third-party agency partner that provides services to Vertex. The individual selected for this role will be offered the role as an employee of that third-party agency; compensation, medical benefits, fringe benefits and other terms and conditions of employment shall be presented by the third-party agency upon offer. The range provided is a reasonable estimate for the pay range for this job at the time of posting. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. The actual pay rate will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com